Rapid Malignant Transformation of Primary Synovial Chondromatosis into Chondrosarcoma

Chondrosarcoma Developing in Synovial Chondromatosis

Synovial chondromatosis is a rare condition in which osteocartilaginous nodules are formed by synovial metaplasia and become intra-articular loose bodies. It is usually monarticular, most commonly affecting the knee and is regarded as invariably benign. There are reports ofmalignant change, but only the two case studies of Mullins, Berard and Eisenberg (1965) and of Dunn et at. (1974) fully doc...

Synovial Chondrosarcoma Arising in Synovial Chondromatosis

Primary synovial chondromatosis (SC) is a rare proliferative disorder that causes pain, swelling, and restriction of movement to the joints it affects. The disease frequently runs a protracted course, often requiring multiple surgical procedures to obtain some control. Few reports exist detailing the natural history of SC, although malignant transformation to synovial chondrosarcoma (CHS) is re...

Malignant Transformation of Synovial Chondromatosis: A Systematic Review

BACKGROUND Synovial chondromatosis (SCh) can undergo malignant transformation. Pathologic diagnosis of secondary synovial chondrosarcoma (SChS) is challenging and misdiagnosis may result in over- or undertreatment. METHOD A systematic review revealed 48 cases of SChS published in 27 reports since 1957. Data was collected to identify findings indicative of SChS and outcomes of treatment. RES...

Synovial Chondromatosis and Chondrosarcoma: A Diagnostic Dilemma

PURPOSE The progression of synovial chondromatosis to chondrosarcoma is very rare. Distinction between these two entities may be difficult on histology alone, and should be based on clinical, radiographic and microscopic evidence. Immunohistochemical markers that would facilitate differentiation between synovial chondromatosis and chondrosarcoma are currently being investigated. PATIENTS We d...

Late malignant transformation of biopsy proven benign synovial chondromatosis: an unexpected pitfall.